To apply for Core membership, please send the following documents to:

Matthew Silva (
silvam@wustl.edu)

  • NIH Biosketch
  • Funding support
  • Paragraph summarizing your research focus

Research Community

The MRC research community has more than 80 members (PIs) who have over 60 million dollars of annual research support (direct costs).

PI Department & Research Focus
Yousef Abu-Amer Orthopaedic Surgery Research

Focus: My laboratory investigates molecular steps critical for development and progression of such diseases related to osteoclasts.
Samuel Achilefu Radiology

Focus: developing new approaches to uncover the molecular basis of diseases through the development of new strategies to image, treat, and monitor treatment response of diseases such as cancer in cells, small animals, and humans.
John Atkinson Internal Medicine-Rheumatology

Focus: uncovering the etiology and pathogenesis of autoimmune rheumatic diseases such as systemic lupus erythematosus, microvascular thrombotic disorders and debris deposition diseases (especially age-related macular degeneration).
Rajeev Aurora Saint Louis University - Molecular Microbiology & Immunology

Focus: to understand the mechanisms that lead to chronic inflammation
David Brogan Orthopaedic Surgery

Focus: to seek ways to improve techniques for peripheral nerve repair and regeneration and has an interest in developing methods to quantitatively assess nerves intra-operatively.
Robert Brophy Orthopaedic Surgery

Focus: Sports medicine and shoulder and knee injuries, with an emphasis on arthroscopic surgery.
William Cade Program in Physical Therapy

Focus: to investigate mechanisms and treatments for skeletal muscle and heart abnormalities in pediatric and adult metabolic disease.
Richard Chole Department of Otolaryngology

Focus: Understanding the mechanisms of bone and tissue destruction in chronic inflammatory diseases of the ear, specifically cholesteatoma.
Roberto Civitelli Internal Medicine - Bone & Mineral Diseases

Focus: understanding the cellular and molecular basis of the bone remodeling process, and to devise mechanisms by which this balance can be modified.
John Clohisy Orthopaedic Surgery

Focus: the diagnosis and treatment of pre-arthritic and early arthritic hip disorders. Optimizing joint replacement procedures in young patients, and total joint arthroplasty patient surveillance.
Clarissa Craft Cell Biology & Physiology

Focus: understanding how the composition of the extracellular matrix (ECM) influences the biochemical and mechanical properties of the cellular microenvironment, and whether the ECM could serve as a therapeutic target for combating diabetes.
David Curiel Department of Radiation Oncology

Focus: To exploit adenoviral agents for applications to the applied contexts of molecular therapeutics.
Michael Diamond Department of Internal Medicine- Infectious Diseases 

Focus: To dissect mechanisms of viral pathogenesis and the host immune response for global pathogens of medical relevance. This includes defining mechanisms of alphavirus-induced arthritis.
Matthew Dobbs Orthopaedic Surgery

Focus: genetic aspects of orthopaedic conditions.
Brian Edelson Pathology & Immunology

Focus: Understanding the function of the transcription factor Bhlhe40 in immune cells.
Roberta Faccio Orthopaedic Surgery

Focus: on the identification of common molecules that can modulate the activation of immune cells as well as osteoclasts.
Brian Finck Department of Medicine

Focus: Understanding the molecular mechanisms involved in lipin 1-deficiency-associated rhabdomyolysis.
James Fitzpatrick Neuroscience

Focus: the integration and application of multi-scale optical and charged particle imaging technologies -- specifically, biological applications of ion microscopy, development of correlative 3D light and electron microscopy approaches, and new computational tools to visualize and manipulate large-scale multi-dimensional datasets.
Richard Gelberman Orthopaedic Surgery

Focus: tendon repair, carpal instability, peripheral nerve repair and peripheral nerve compression.
Jeffrey Gordon Pathology & Immunology

Focus: Developing a translational research pipeline for identifying next generation prebiotics, probiotics- and synbiotics (combinations of pre- and probiotics) to prevent or treat metabolic dysfunction and nutritional deficiencies
Jianjun Guan Mechanical Engineering and Materials Science

Focus: biomimetic biomaterials synthesis and scaffold fabrication; bioinspired modification of biomaterials; injectable and highly flexible hydrogels; bioimageable polymers for MRI and EPR imaging and oxygen sensing; mathematical modeling of scaffold structural and mechanical properties; stem cell transplantation; and regeneration of musculoskeletal, cardiovascular and brain tissues.
Farshid Guilak Orthopaedic Surgery

Focus: Cell and Tissue Engineering; Development, Degeneration, and Aging; Embryonic and Adult Tissue Stem Cells
Christina Gurnett Neurology

Focus: the genetic basis of congenital malformations such as idiopathic scoliosis and clubfoot.
Charles Harris Endocrinology, Metabolism and Lipid Research

Focus: Molecular mechanisms of glucocorticoid action.
Michael Harris Physical Therapy

Focus: How alterations in joint geometry or the musculature affect movement patterns and how these factors are collectively associated with osteoarthritis (OA).
Marcie Harris Hayes Physical Therapy

Focus: Biomechanics and Imaging of the hip and pelvis with the goal to develop effective rehabilitation strategies for people with musculoskeletal hip disorders.
Mary Hastings Program in Physical Therapy

Focus: Foot and ankle biomechanics; understanding of foot and ankle function to improve screening, prevention, and treatment outcomes related to foot and ankle injuries.
Andreas Herrlich Renal Division

Focus: Understand the regulation of the release of growth factors and cytokines by metalloproteases cleavage from the cell surface (ectodomain cleavage), how it affects communication between different cell types in complex multicellular organs, and its role(s) in pathophysiology.
Angela Hirbe Division of Onocology

Focus: Utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.
Keiko Hirose Department of Otolaryngology

Focus: Innate immunity of the inner ear and how it influences cochlear structure and function.
Didier Hodzic Department of Ophthalmology and Visual Sciences

Focus: Mechanisms of nuclei positioning in tissue development/homeostasis
Keith Hruska Pediatrics Nephrology

Focus: the pathogenesis and pathophysiologic mechanisms of the chronic kidney disease-bone and mineral disorder.
Michael Hughes Medicine - Pulmonary

Focus: to understand tissue specific gene expression in circadian rhythms, skeletal muscle, and lung disease using functional genomics.
Benjamin Humphreys Division of Renal Diseases

Focus: Understanding mechanisms of fibrosis across organs in chronic injury states. We study myofibroblast progenitor cell populations with a focus on the hedgehog-gli pathway, using mouse model systems as well as translational approaches with human samples.
Aaron Johnson Developmental Biology

Focus: identifying the molecular mechanisms that govern skeletal muscle development.
Jay Keener Orthopaedic Surgery

Focus: Evaluation and treatment of shoulder and elbow disorders, including throwing shoulder injuries, labral tears and biceps tendon injuries, rotator cuff disease and tears, frozen shoulder syndrome, shoulder and elbow arthritis, shoulder fractures, minimally invasive shoulder fracture fixation, shoulder and elbow joint replacement, acromioclavicular and sternoclavicular joint injuries, shoulder instability and reverse shoulder arthroplasty. .
Spencer Lake Mechanical Engineering, Materials Science and Biomedical Engineering

Focus: Multiscale mechanics of orthopaedic soft tissues, particularly of tendons and ligaments that are subjected to complex and/or combined physiologic loads.
Gregory Lanza Medicine & Biomedical Engineering

Focus: Development of novel nanotechnologies for biomedical molecular imaging and targeted drug delivery in cardiovascular, neurological, orthopedic, rheumatoid, and cancer diseases.
Deborah Lenschow Department of Rheumatology

Focus: Understanding the mechanism by which type I IFNs mediate their effector mechanisms through the study of various IFN stimulated genes.
Daniel Link Internal Medicine

Focus: Mechanisms that regulate normal and leukemic hematopoiesis.
Gabriel Mbalaviele Bone & Mineral Diseases

Focus: The role of the Leucine rich Repeat with a Pyrin domain 3 (NLRP3) inflammasome in bone.
Audrey McAlinden Orthopaedic Surgery

Focus: on cartilage tissue, both articular and growth plate cartilage.
Sara McBride-Gagyi Saint Louis University - Orthopaedic Surgery

Focus: Investigating the role of bone morphogenetic protein two (BMP2) on skeletal development and bone quality.
Douglas McDonald Orthopaedic Surgery

Focus: Investigate how comorbidities such as obesity and potential therapies such as mesenchymal stem cell injections contribute to the development of post-traumatic arthritis. 
Robert Mecham Cell Biology & Physiology

Focus: to understand the complex process of extracellular matrix secretion and assembly, with a particular emphasis on the proteins important to the cardiovascular and pulmonary systems.
Gretchen Meyer Physical Therapy & Neurology

Focus: Understanding how changes at the molecular and cellular level in skeletal muscle affect muscle structure and function.
Kevin Middleton University of Missouri - Pathology

Focus: on the integrative biology and evolution of vertebrate “locomotor tissues” including not only bones and muscles but also feathers and wing membranes.
Bettina Mittendorfer Geriatrics

Focus: investigation of (i) fatty acid and lipoprotein metabolism leading to the discovery of significant sexual dimorphism in the regulation of lipid metabolism and (ii) muscle protein metabolism with the goal to elucidate the influences of sex hormones, male/female genotype and fibre composition on the muscle anabolic response to feeding and exercise.
Steven Mumm Internal Medicine - Bone & Mineral Diseases

Focus: the molecular genetics of metabolic bone diseases and skeletal dysplasias, with special emphasis on the patient population at the Center for Metabolic Bone Disease and Molecular Research, Shriners Hospitals for Children, St. Louis.
Nicola Napoli Bone & Mineral Diseases

Focus: pharmacogenetics of osteoporosis, with emphasis on estrogen metabolic pathways, on the effects of bisphosphonates and other pharmacologic agents in osteoporosis, and on the effects of diabetes on bone health.
Jeffrey Nepple Orthopaedic Surgery

Focus: young adult hip disorders and pediatric sports medicine.
Regis O'Keefe Orthopaedic Surgery

Focus: Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone.
David Ornitz Developmental Biology

Focus: Examining mechanisms by which growth factors modulate skeletal fracture repair.
Russell Pachynski Dept. of Medicine | Oncology Division

Focus: The impact of chemerin modulation in mouse models of prostate cancer.
Cecilia Pascual-Garrido Orthopaedic Surgery

Focus: cartilage regeneration, hip dysplasia, hip impingement, biomarkers, tissue engineering, stem cells, osteoarthritis.
Debabrata Patra Orthopaedic Surgery

Focus: gene regulation of extracellular matrix proteins and its influence on the phenotype of cells.
Tim Peterson Bone & Mineral Diseases

Focus: To better understand mineralization during aging and the roles that naturally occurring phosphonates play in mammalian physiology and disease.
Christine Pham Rheumatology

Focus: Defining the role of proteases in immunity and autoimmunity.
M. Farooq Rai Orthopaedic Surgery

Focus: understanding the early molecular mechanisms that orchestrate changes in knee joint after injury and lead to the development of osteoarthritis.
Linda Sandell Orthopaedic Surgery

Focus: Molecular mechanisms of cartilage development and disease.
Erica Scheller Bone & Mineral Diseases

Focus: The impact of neuroendocrine signals on bone loss and marrow adiposity in diseases including periodontitis, arthritis, and diabetes.
Lori Setton Biomedical Engineering

Focus: Development of imaging and fluid-based biomarkers of disease to characterize therapy benefits for pain and dysfunction.
Hua Shen Orthopaedic Surgery

Focus: biological and mechanical factors that regulate tendon development, injury, and repair, as a basis to develop new therapeutic approaches to improve tendon healing.
Jie Shen Orthopaedic Surgery

Focus: Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone.
Monica Shokeen Radiology

Focus: Develop and evaluate molecularly targeted small molecule and multi-functional macromolecular bio-conjugates for nuclear and optical imaging of cancer and cardiovascular diseases. We are currently developing multi-modal imaging platforms for studying bone marrow related malignancies such as multiple myeloma.
Allison Snyder-Warwick Surgery

Focus: Facial reconstruction, facial nerve disorders, facial paralysis, facial clefts, cleft lip, cleft palate, ear reconstruction, microtia, reconstruction of obstetrical brachial plexus injuries, microsurgical procedures in children and adults.
Matthew Silva Orthopaedic Surgery

Focus: Fusing biology and biometrics.
Lilianna Solnica-Krezel Developmental Biology

Focus: investigating the cellular and molecular genetic mechanisms underlying vertebrate gastrulation, a crucial period of embryogenesis during which the germ layers are formed and then shaped into the vertebrate body plan with organ rudiments.
Sheila Stewart Cell Biology & Physiology

Focus: How aging impacts the tumor microenvironment.
Simon Tang Orthopaedic Surgery

Focus: (1) understanding the effect of disease mechanisms on the structure-function relationships of skeletal tissues and (2) developing of translatable therapeutic and regenerative strategies for these diseases. The investigation of these scientific questions includes the application of finite element analyses, multiscale tissue mechanics, the functional imaging of skeletal tissues, and development of nanostructures and nanomaterials for regenerative medicine with in vitro and in vivo biological systems.
Steven Teitelbaum Pathology & Immunology

Focus: Study of osteoporosis.
Linda VanDillen Physical Therapy

Focus: 1) the sensory-motor factors underlying musculoskeletal pain conditions, and 2) how these factors interact with activity demand and psychsocial factors to increase risk for, or contribute to an existing musuloskeleletal pain condition.
Deborah Veis Bone & Mineral Diseases

Focus: Human and rodent bone diseases.
Brian Van Tine Oncology

Focus: Understanding the initiation, progression and relapse mechanisms of osteosarcoma.
Conrad Weihl Neurology

Focus: Histology.
Katherine Weilbaecher Internal Medicine

Focus: Understanding the molecular basis of bone metastasis, with a particular interest in the critical roles of osteoclast and osteoblast beta 3 integrin signaling pathway genes, the viral oncogene, Tax, and the bone marrow homing molecules, VLA-4, CXCR4 and G-CSF in the process of bone metastasis and multiple myeloma bone marrow colonization.
Michael Whyte Internal Medicine - Bone & Mineral Diseases

Focus: metabolic and dysplastic bone disease in children.
Matthew Wood Plastic and Reconstructive Surgery

Focus: Understanding mechanisms contributing to nerve regeneration following surgical reconstruction, specifically the reconstruction of long nerve defects.
David Wozniak Psychiatry

Focus: the role of NMDA glutamate receptors in learning and memory and in the neuropathologic changes and cognitive decline associated with aging and rodent models of Alzheimers disease.
Rick Wright Orthopaedic Surgery

Focus: knee ligament healing and clinical problems involving the shoulder.
Wei Zou Anatomic & Molecular Pathology

Focus: the mechanisms by which osteoclasts degrade bone and as a result our trainees have become the leaders in the field of bone biology.