Structure and Strength Core

Director

Matt Silva
(314) 362-8585
silvam@wustl.edu

Associate Directors

Simon Tang
(314) 286-2664
simon.tang@wustl.edu

Gretchen Meyer
(314) 286-1425
meyerg@wustl.edu

Research Administator

Tonia Thompson
(314) 747-2532
thompsont@wustl.edu

Administrative Coordinator

Orthopaedic Surgery
Kamilla McGhee
P. (314) 747-5993
F. (314) 454-5900
kjm@wustl.edu

Overview


We are pleased to announce that Mr. Yung Kim will join the Structure and Strength Core as Research Lab Supervisor, filling the vacancy left by Dan Leib’s departure. Mr. Kim has a BS degree in BME from University of Utah, and has experience with microCT and as a core lab imaging specialist at the University of Minnesota. He will join us early in 2019.



Measures of structure and strength are essential when assessing functional outcomes in animal models related to musculoskeletal biology and medicine. In 2008, evaluation of these outcomes at Washington University in Saint Louis (WUSTL) was limited to few investigators because we lacked centralized resources and organization. Evaluating these outcomes requires specialized equipment and expertise, which is impractical and inefficient to recreate in multiple labs. In response to this unmet need, we established the Musculoskeletal Structure and Strength Core. This multifaceted resource supports our Research Community in understanding and implementing techniques to evaluate structure and mechanical properties of musculoskeletal tissues (bone, cartilage, disc, muscle, tendon) derived from animal models. The Structure and Strength core has five objectives: A) support access and cost-effective utilization of existing resources for imaging and mechanical testing; B) support rigorous approaches leading to publication quality data with broad impact; C) provide training and enrichment opportunities (in concert with the T32 Skeletal Disorders Training Program); D) enhance and extend Core capabilities through development of new techniques; and E) foster new interactions and enhance existing interactions between members of the musculoskeletal Research Community at WUSTL.

  • Aim 1 – Imaging
  • Aim 2 – Mechanical Testing

 

Equipment

Radiography. Digital Radiography System, Faxitron Model UltraFocus100 (Location: BJCIH 11506; Contact:Michael Brodt, brodtm@wustl.edu)

Dual-Energy X-Ray Absorptiometry (DXA): Faxitron Model UltraFocus100  (Location: BJCIH 11506; Contact: Michael Brodt, brodtm@wustl.edu

MicroCT – post mortem: Scanco uCT40 (Location: BJCIH 11506; Contacts: Michael Brodt, brodtm@wustl.edu)

MicroCT – in vivo: Scanco VivaCT40 (Location: BJCIH 11506; Contact: Michael Brodt, brodtm@wustl.edu)

X-ray Microscope: Zeiss Xradia Versa520 High Resolution/NanoCT (Location: Couch Bldg., WU Center for Cellular Imaging (WUCCI); Contact: James Fitzpatrick, fitzp@wustl.edu)

Mechanical Testing: Instron 8841 (200 lb, servohydraulic), Instron 5866 (2000 lb, electromechanical), Instron ElectroPuls E1000 (1000 N, electromechanical); Qualysis Oqus sytem for motion capture; Location: BJCIH 11518; Contact: Matt Silva, silvam@wustl.edu; Michael Brodt, brodtm@wustl.edu)

Muscle Physiology: For in vitro and in vivo testing of muscles in mice, please contact Dr. Gretchen Meyer (https://pt.wustl.edu/research/integrative-muscle-physiology/ 314-286-1425; meyerg@wustl.edu).

 

CORE SERVICES [PDF]


Citing the grant in publications:


“Washington University Musculoskeletal Research Center (NIH P30 AR057235)”